What is the Difference Between Vitamin B6 and Vitamin B12

Difference Between Vitamin B6 and Vitamin B12 – This is the primary difference between B complex and B12. That vitamin B12 is often considered a part of the B complex. Vitamin B complex supplements usually include all of the B vitamins, including vitamins B1, B2, B3, B5, B6, B7, B9 and B12. All of which are very essential for the body. Vitamins are important nutrients for the normal functioning of the body’s various enzymes and metabolic pathways.

Vitamins B-6 and B-12, also known as pyridoxine and cobalamin. They both belong to the family of eight B-complex vitamins. Along with other B vitamins, they help convert food into energy. and nourish your skin and liver. But several key differences separate vitamins B-6 and B-12. in which they are used in your body. And that includes their potential for side effects.

Difference Between Vitamin B6 and Vitamin B12

Vitamin B6Vitamin B12
Vitamin B6 is a water-soluble vitamin commonly known as pyridoxine.Vitamin B12 is a water-soluble vitamin also known as cobalamin.
The molecular formula of vitamin B6 is C₈H₁₁NO₃.The molecular formula of vitamin B12 is C63H88CoN14O14P.
Chicken, beef, fish, sweet potatoes and bananas are sources of vitamin B6.Clams, liver, dairy products, fish and meat are sources of vitamin B12.
Vitamin B6 is beneficial in making hemoglobin and regulating blood pressure.Vitamin B12 is helpful in nervous system and cardiovascular system function.
Microcytic anemia and chapped lips indicate vitamin B6 deficiency.Megaloblastic anemia refers to a deficiency of vitamin B12.

What is Vitamin B6?

Vitamin B6 is an essential factor in RBC metabolism and efficient functioning of the immune and nervous systems. The vitamin is readily available in fortified cereals, meat, fish, poultry, fruits and vegetables. Tryptophan is converted to niacin by vitamin B6. Vitamin B6 has some major functions such as maintaining your blood sugar and producing hemoglobin. In fasting when the calorie level decreases. So the body synthesizes glucose from other carbohydrates using vitamin B6. It is also required for efficient immune response and antibody production.

Vitamin B6 deficiency can lead to dermatitis, glossitis, confusion, depression, and convulsions. Sometimes it can also cause anemic condition. These symptoms are more common. Therefore it cannot be attributed to the deficiency of Vitamin B6 alone. Symptoms appear at a later stage after nutrient deficiency. An upper tolerable level for adults has been found to be 100 mg per day. And once this limit is crossed. So the body usually shows adverse effects. Too much of the vitamin can also cause neuropathy.

What is Vitamin B12?

Vitamin B12 is a water-soluble vitamin. which is found in bound form in animal products. It is released by the action of hydrochloric acid and gastric protease. Vitamins are needed for the formation of red blood cells, DNA synthesis and the function of nervous tissue. Deficiency leads to severe type of anemia. Which is called perinaemia anemia. Which happens in older people. More  evidence is needed to prove the effects of using vitamin B12 in other conditions such as aging, immune system functioning, memory loss, etc.

If one left untreated results in irreversible megaloblastic anemia and disorders of the nervous system. The vitamin is involved in the formation of methylmalonyl CoA. The molecule is therefore an effective indicator for vitamin B12 levels. The ability to absorb vitamin B12 from the diet varies according to a person’s makeup. Oral and sublingual supplements are available. A vegetarian diet does not provide sufficient amounts of vitamin B12. Thus there is a need for supplements. It is also important for myelin synthesis and repair.

What is the Difference Between Vitamin B6 and Vitamin B12?

  • Both vitamins are effective in reducing homo-cysteine ​​levels in the blood.
  • Vitamin B6 and vitamin B12 are both involved in the conversion of homocysteine ​​to methionine.
  • Vitamin B12 requires a transcobalamin molecule to transport the vitamin across tissues.
  • Whereas vitamin B6 does not require any specific transporter.
  • Deficiencies of both vitamins can affect neurological functions.
  • The absorption of vitamin B12 is mediated by an intrinsic factor.
  • Food bound vitamin B12 is bound to haptocorin (R-protein).
  • which needs to be cleaved and released for the action of pancreatic enzymes.
  • The effects of a deficiency in vitamin B12 are more pronounced than in vitamin B6.
  • The primary causes of vitamin B12 deficiency include vegetarian diet, impaired absorption and inadequate utilization etc.
  • Common sources of vitamin B6 are fruits and vegetables and a vegetarian diet does not impede adequacy of the vitamin in the diet.
  • Vitamin B12 levels are significantly reduced in a vegetarian diet.
  • Dietary deficiencies with vitamin B6 are rare. But severe and chronic deficiency can lead to the disease pellagra.


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